A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development

A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control nuclear envelope breakdown (NEBD), centrosome maturation, spindle assembly, chromosome segregation, cytokinesis. In vertebrates, an important player during oogenesis preimplantation development. pathways regulating mRNA translation, involved of mammalian target rapamycin complex 1 (mTORC1) thereby activity translational repressor, eukaryotic initiation 4E (eIF4E) binding (4E-BP1). this review, we summarize functions mitosis, meiosis early embryonic Additionally, role regulation translation addressed with respect to significance process